Zavisol 5% Cream – Acyclovir for Cold Sores and Herpes ReliefZavisol 5% Cream Acyclovir for Cold Sores and Herpes Simplex Treatment Zavisol 5% Cream contains Acyclovir 50mg g, a nucleoside analogue antiviral agent used for the topical treatment of herpes simplex labialis (cold sores) and recurrent herpes simplex infections of the skin. Applied at the first sign of an outbreak tingling, itching, or redness the cream reduces the severity of lesions, shortens healing time, and relieves associated pain and